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  • Title: L-arginine is effective in stroke-like episodes of MELAS associated with the G13513A mutation.
    Author: Shigemi R, Fukuda M, Suzuki Y, Morimoto T, Ishii E.
    Journal: Brain Dev; 2011 Jun; 33(6):518-20. PubMed ID: 20832210.
    Abstract:
    We report a case involving a 15-year-old boy with MELAS (G13513A mutation) who developed several stroke-like episodes in a short period of time. Intravenous administration of l-arginine during the acute phase of the stroke-like episodes reduced symptoms immediately, and oral supplementation of l-arginine successfully prevented further stroke-like episodes. This is the first report on effective l-arginine therapy in MELAS associated with the G13513A mutation.
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