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  • Title: Fibrin d-dimer concentration, deep vein thrombosis symptom duration, and venous thrombus volume.
    Author: Kurklinsky AK, Kalsi H, Wysokinski WE, Mauck KF, Bhagra A, Havyer RD, Thompson CA, Hayes SN, McBane RD.
    Journal: Angiology; 2011 Apr; 62(3):253-6. PubMed ID: 20834027.
    Abstract:
    INTRODUCTION: To determine the relationship between fibrin D-dimer levels, symptom duration, and thrombus volume, consecutive patients with incident deep venous thrombosis (DVT) were evaluated. METHODS: In a cross-sectional study design, patient symptom onset was determined by careful patient questioning. Venous thrombosis was confirmed by compression duplex ultrasonography. Thrombus volume was estimated based on patient's femur length using a forensic anthropology method. Fibrin D-dimer was measured by latex immunoassay. RESULTS: 72 consecutive patients with confirmed leg DVT agreed to participate. The median symptom duration at the time of diagnosis was 10 days. The median D-dimer concentration was 1050 ng/dL. The median thrombus volume was 12.92 cm(3). D-Dimer levels correlated with estimated thrombus volume (P < .0006 CI 0.12-0.41; R(2) (adjusted) = .15) but not symptom duration, patient's age, or gender. CONCLUSIONS: Despite varying symptom duration prior to diagnosis, fibrin D-dimer remains a sensitive measure of venous thrombosis and correlates with thrombus volume.
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