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  • Title: IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship.
    Author: Kawahara S, Iwata I, Fujita E, Yamawaki M, Nishiwaki H, Sugahara T, Yamauchi S, Akiyama K, Kishida T.
    Journal: Biosci Biotechnol Biochem; 2010; 74(9):1878-83. PubMed ID: 20834158.
    Abstract:
    The IgE-suppressive activity of (-)-matairesinol is demonstrated, and the structure-activity relationship of (-)-matairesinol clarified. 3',4-Dihydroxy-3,4'-dimethoxylignano-9,9'-lactone showed higher IgE-suppressive activity than (-)-matairesinol without any cytotoxic activity. Some derivatives bearing a longer and more bulky alkoxy group at the 3 or 4 position showed IgE-accelerative activity.
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