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  • Title: [Physiological basis of goiter transformation of the thyroid gland and the pathogenesis of euthyroid goiter].
    Author: Aleshin BV.
    Journal: Fiziol Zh (1978); 1990; 36(6):115-20. PubMed ID: 2083579.
    Abstract:
    Endemic goiter disease develops as a result of iodine insufficiency in the environment, that induces advancing reproduction of thyrocytes realized by endomitosis. Eventually goiter-transformed gland ceases responding to the lack of iodine in the environment, that is due to the destruction of thyrocyte ++thyroreceptors. It should be taken into account that goiter disease depends upon the female sexual hormones.
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