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  • Title: Microbial transformation of asiatic acid by Alternaria longipes.
    Author: He WN, Dai JG, Ye M, Wu LJ, Guo DA.
    Journal: J Asian Nat Prod Res; 2010 Sep; 12(9):760-4. PubMed ID: 20839122.
    Abstract:
    Asiatic acid is a major pentacyclic triterpene isolated from Centella asiatica. It shows a variety of bioactivities. In order to obtain its derivatives, potentially useful for detailed pharmacological studies, the substrate was subjected to incubations with selected micro-organisms. In this work, asiatic acid was converted into three new compounds: 2α,3β,23,30-tetrahydroxyurs-12-ene-28-oic acid (1), 2α,3β,22β,23-tetrahydroxyurs-12-ene-28-oic acid (2), and 2α,3β,22β,23,30-pentahydroxyurs-12-ene-28-oic acid (3) by the fungus Alternaria longipes AS 3.2875. The structures of the three metabolites were determined by 1D and 2D NMR spectral data.
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