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  • Title: Cardiac troponin T detection using polymers coated quartz crystal microbalance as a cost-effective immunosensor.
    Author: Wong-ek K, Chailapakul O, Nuntawong N, Jaruwongrungsee K, Tuantranont A.
    Journal: Biomed Tech (Berl); 2010 Oct; 55(5):279-84. PubMed ID: 20840005.
    Abstract:
    Cardiac troponin T (cTnT) detection has been the focus of increased interest due to its role in myocardial infarction diagnosis. In this study, we report a relatively low coat technique to detect cTnT using a quartz crystal microbalance (QCM) sensor. A sensitive detection is achieved by introducing a QCM surface with a carboxylic polyvinyl chloride immobilization layer. The surface morphologies of this polymer film under varied deposition thickness have been investigated by field emission scanning electron microscopy and atomic force microscopy. A cTnT detection result from a modified QCM surface can be obtained within a short response time by a direct detection of the immunoreaction and a direct conversion of mass accumulation into a frequency shift, representing a measurable electrical signal. The relationship between the cTnT concentration and the response current from a QCM sensor shows detectability at the concentration of cTnT as low as 5 ng/ml.
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