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  • Title: Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis.
    Author: Lee HZ, Yang WH, Hour MJ, Wu CY, Peng WH, Bao BY, Han PH, Bau DT.
    Journal: Eur J Pharmacol; 2010 Dec 01; 648(1-3):50-8. PubMed ID: 20840846.
    Abstract:
    Aloe-emodin was found to be a photosensitizer and possess anti-tumor activity. However, the detailed mechanism underlying the biological effects of aloe-emodin remains unknown. In this study, we explored the mechanisms of photocytotoxicity induced by aloe-emodin in lung cancer H460 cells. According to the results of the photoactivated aloe-emodin-induced disruption of cytoskeleton, we verify that aloe-emodin with irradiation induces anoikis of H460 cells. Photosensitized aloe-emodin-induced anoikis is associated with the protein expression of α-actinin and mitogen-activated protein (MAP) kinase members. In this study, a rapid opening of the mitochondrial permeability transition pore and the change in apoptosis-related protein expression were involved in photoactivated aloe-emodin-induced cell death. We also demonstrated that anoikis induced by aloe-emodin with irradiation is mediated through the intrinsic and extrinsic death pathways in a caspase-dependent manner in H460 cells.
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