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  • Title: Corin: an ANP protease that may regulate sodium reabsorption in nephrotic syndrome.
    Author: Klein JD.
    Journal: Kidney Int; 2010 Oct; 78(7):635-7. PubMed ID: 20842148.
    Abstract:
    The serine/threonine protease corin, which proteolytically activates atrial natriuretic peptide (ANP), is reduced in the kidneys of animals with nephrotic syndrome and glomerular nephritis. Polzin et al. provide evidence for a linkage between the decreased corin and β-epithelial sodium channel, phosphodiesterase 5, and cGMP-dependent protein kinase II in the nephrotic kidney. They propose that decreases in cGMP resulting from the reduced corin may be responsible for the Na(+) retention and volume expansion that are hallmarks of these kidney diseases.
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