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  • Title: The distribution of S-100 protein in articular cartilage from osteoarthritic joints.
    Author: Chen F, Kerner MB, Dorfman HD, Hamerman D.
    Journal: J Rheumatol; 1990 Dec; 17(12):1676-81. PubMed ID: 2084243.
    Abstract:
    The distribution and localization of S-100 protein was compared with safranin-O staining and H and E morphology in relatively unaffected, degenerative, and osteophytic regions of human articular cartilage from 26 joints obtained at the time of total joint replacement for osteoarthritis. S-100 protein immunoreactivity in osteophyte cartilage was more intense than in unaffected regions and comparable to the staining intensity found in metaplastic cartilage tufts in degenerating cartilage. Immunoreactivity for S-100 protein appeared more prominent in the deep layers of osteophyte cartilage adjacent to areas of matrix calcification.
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