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  • Title: A late form of neurosyphilis manifesting with psychotic symptoms in old age and good response to ceftriaxone therapy.
    Author: Güler E, Leyhe T.
    Journal: Int Psychogeriatr; 2011 May; 23(4):666-9. PubMed ID: 20843397.
    Abstract:
    Neurosyphilis can present with psychiatric symptoms. The late form can occur in old age with psychosis, paranoid delusions, affective disorders or cognitive impairment. Here we present a case of neurosyphilis in an elderly woman who, over six months, progressively manifested personality changes and paranoid delusions which were initially suspected as Alzheimer's disease. Psychotic symptoms showed a good response to antibiotic treatment. We conclude that neurosyphilis is a relevant differential diagnosis in patients developing severe psychiatric symptoms in old age. As a causal antibiotic treatment is possible this infectious disease should be considered seriously in gerontopsychiatric patients.
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