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  • Title: Oxygen derived free radicals and the course of Eimeria vermiformis infection in inbred strains of mice.
    Author: Ovington KS, Smith NC, Joysey HS.
    Journal: Parasite Immunol; 1990 Nov; 12(6):623-31. PubMed ID: 2084608.
    Abstract:
    Free radical generation by peritoneal leukocytes from BALB/c and C57BL/6 mice was monitored for 18 days following infection with Eimeria vermiformis. Free radical generation occurred earlier and was quantitatively much greater in resistant BALB/c mice than in susceptible C57BL/6 mice, resistance being indicated by a much lower oocyst production and a shorter patent period of E. vermiformis. Plasma greatly enhanced free radical generation in response to a soluble antigen prepared from sporulated oocysts indicating the presence of plasma-borne factor(s) which enhance free radical generation in response to E. vermiformis.
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