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  • Title: [Effects of high mobility group box 1 in activating periodontal ligament fibroblasts to express cytokine].
    Author: Sun QF, Xu Y, Song H, Hu YW, Yang PS.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Aug; 28(4):443-6. PubMed ID: 20848944.
    Abstract:
    OBJECTIVE: To investigate the influence of high mobility group box 1 (HMGB1) on the expression of interleukin 6 (IL-6), receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) on periodontal ligament fibroblasts. METHODS: Human periodontal ligament fibroblasts were stimulated with HMGB1 at concentrations of 10, 30, and 100 ng x mL(-1) for 24 h. RT-PCR and Western blot analysis were performed to check mRNA and protein expression of IL-6, RANKL and OPG on the cells. RESULTS: The ratio of RANKL/OPG was increased at both mRNA and protein level after HMGB1 stimulation at 10, 30, 100 ng x mL(-1). Inflammatory cytokine IL-6 was upregulated by HMGB1 at the concentration of 100 ng x mL(-1). CONCLUSION: Increased ratio of RANKL/OPG and IL-6 on periodontal ligament fibroblasts suggests that HMGB1 might play a role in the pathogenesis and progression of periodontal disease.
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