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  • Title: Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives.
    Author: Patel MM, Mali MD, Patel SK.
    Journal: Bioorg Med Chem Lett; 2010 Nov 01; 20(21):6324-6. PubMed ID: 20850303.
    Abstract:
    The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram +ve), Escherichia coli, Pseudomonas aeruginosa (gram -ve) and antifungal activity against Aspergillus niger and anticancer activity (HL-60, Hep-2 & HEK293T) by MTT assay. Chloro substituted compounds showed antimicrobial and anticancer activity with IC(50) values in the low micromolar range.
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