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  • Title: Potentially life-threatening cardiac dysrhythmia in a child with selenium deficiency and phenylketonuria.
    Author: Greeves LG, Carson DJ, Craig BG, McMaster D.
    Journal: Acta Paediatr Scand; 1990 Dec; 79(12):1259-62. PubMed ID: 2085118.
    Abstract:
    Selenium deficiency is a frequent finding in children with phenylketonuria (PKU) receiving dietary treatment. We report the occurrence of episodic ventricular tachycardia in a 9-month-old infant with PKU. Serum selenium (Se), 0.13 mumol/l (normal range 0.28-1.12 mumol/l, mean +/- 2 SD), and whole blood glutathione peroxidase (GSHPX), 16 U/g Hb (normal range 19.5-34.3 U/g Hb, mean +/- 2 SD), were low. Auscultation of cardiac rhythm is recommended during the routine follow-up of young children with PKU. Se deficiency should be considered in the aetiology of a dysrhythmia and corrected with Se supplementation.
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