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  • Title: The relation between the duty cycle and anesthetic effect in lidocaine iontophoresis using alternating current.
    Author: Wakita R, Nakajima A, Haida Y, Umino M, Fukayama H.
    Journal: Pain Pract; 2011; 11(3):261-6. PubMed ID: 20854308.
    Abstract:
    We assessed the effect of the duty cycle on the anesthetic effect during lidocaine alternating current (AC) iontophoresis. A solution of 2% lidocaine was delivered to the medial antecubital skin for 20 minutes using AC iontophoresis with a duty cycle of 60%, 70%, or 80%. The von Frey test was then performed to evaluate the anesthetic effect. In the groups treated with a duty cycle of 80% or 70% the touch thresholds (TT) were significantly elevated from 0 minutes to 30 minutes and from 0 minutes to 20 minutes. TT were significantly elevated at 0 minutes in the group treated with a 60% duty cycle. The anesthetic effect was significantly enhanced in a duty cycle-dependent manner.
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