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  • Title: Clinical evaluation of the imipenem/cilastatin combination in the therapy of severe infections in patients with malignant diseases.
    Author: Cristiano P, Iovene MR, Simioli F, Pezza M, Raucci G, Lobello R.
    Journal: Drugs Exp Clin Res; 1990; 16(6):293-7. PubMed ID: 2086164.
    Abstract:
    Thirty hospitalized patients (23 men and 7 women), aged 42 to 78 years, with impaired host defences for malignant underlying diseases and affected by life-threatening infections, were treated with the imipenem/cilastatin combination at a dosage ranging between 2 and 4 g daily i.v. at 8 or 12 h intervals. The average length of therapy was 9.6 +/- 2.09 days. The isolated organisms were as follows: Pseudomonas aeruginosa [12], Escherichia coli [10], Klebsiella pneumoniae [5], Proteus mirabilis [3], P. vulgaris [2], Serratia marcescens [1], Staphylococcus aureus [3], Streptococcus faecalis [3], Bacteroides fragilis [5]. In fourteen patients a mixed infection was observed. Twenty-three patients (76.66%) were completely cured of infection and 35 out of 44 isolated organisms (79.54%) were eradicated. No important side-effects were observed.
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