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  • Title: [Researched of PJ34 which is protective effect on the glutamate-induced HT-22 cell damage].
    Author: Fan HB, Wang YN, Geng DQ.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2010 Jul; 26(7):712-3. PubMed ID: 20862804.
    Abstract:
    AIM: To poly ADP ribose polymerase inhibitors PJ34 on glutamate neurotoxicity induced protective effect, as PJ34 in ischemic cerebrovascular disease provide a reference for clinical applications. METHODS: After the cultured HT-22 cells were treated with 5 mmol/L Glu induction treatment, divided into the PJ34 group subsequently given 50 micromol/L PARP inhibitor PJ34 protection effects processing. Inhibition rate of each group and the PARP activity of changes. RESULTS: PJ34 group after 24 h, inhibition rate of HT-22 cells were markedly decreased (P<0.05). PJ34 PARP activity than the control group was significantly lower (P<0.05). CONCLUSION: PJ34 PARP activity by reducing increased glutamate-induced HT-22 cell viability, and thus play a protective effect on cells.
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