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  • Title: Ischemic conditioning of the gastric conduit prior to esophagectomy improves mucosal oxygen saturation.
    Author: Bludau M, Hölscher AH, Vallböhmer D, Gutschow C, Schröder W.
    Journal: Ann Thorac Surg; 2010 Oct; 90(4):1121-6. PubMed ID: 20868800.
    Abstract:
    BACKGROUND: Ischemic conditioning of the gastric conduit is considered as a possible approach to improve perfusion of the gastric tube after esophagectomy. The aim of this study was to assess the impact of ischemic conditioning on gastric microcirculation in a clinical setting. METHODS: Nineteen patients with an esophageal carcinoma were included. In a first laparoscopic procedure, the stomach was devascularized by complete gastric mobilization including ligation of the left gastric artery ("laparoscopic gastrolysis"). After a delay of 4 to 5 days, all patients underwent a transthoracic esophagectomy and reconstruction with the prepared gastric conduit (Ivor-Lewis). Mucosal oxygen saturation (MOS, sulfur dioxide in %) was quantitatively measured from the endoluminal side in well-defined areas of the antrum, corpus, and fundus using a tissue spectrometer located at the tip of a microprobe (LEA, Medizintechnik, Giessen, Germany). Under general anesthesia, sulfur dioxide measurement I was taken before, and measurement II after laparoscopic gastric mobilization; measurement III was done before esophagectomy and reconstruction 4 to 5 days later. RESULTS: Before laparoscopic mobilization of the stomach the median MOS of the fundus was 72% (range, 49% to 86%). The MOS significantly decreased after devascularization of the stomach (median MOS, 38%; range, 9% to 86%). After 4 to 5 days, MOS almost recovered to values observed before gastric mobilization (median MOS, 62%; range, 48% to 85%). Compared with the fundus, no significant sulphur dioxide changes were detected in the corpus and antrum. CONCLUSIONS: This study demonstrates that ischemic conditioning influences microcirculation of the gastric conduit and improves MOS in the anastomotic region at the time of reconstruction.
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