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  • Title: [Osteoprotegerin and bone mineral density in patients with chronic obstructive pulmonary disease].
    Author: Kochetkova EA, Nevzorova VA, Maĭstrovskaia IuV, Massard G.
    Journal: Ter Arkh; 2010; 82(8):10-4. PubMed ID: 20873238.
    Abstract:
    AIM: to study a relationship between the serum level of osteoprotegerin (OPG), the markers of bone metabolism, tumor necrosis factor-alpha (TNF-alpha), and bone mineral density (BMD) in patients with chronic obstructive pulmonary disease (COPD). SUBJECTS AND METHODS: Fifty-five patients aged 44 to 58 years who had COPD were examined. BMD in the lumbar spine (L(II)-L(IV)) and left femoral neck (FN) was estimated by dual-energy X-ray absorptiometry (DXA) on Lunar Prodigy Densitometer (USA). The serum levels of OPG, BCrossLaps (BCL), and TNF-alpha were measured. A control group comprised 25 healthy non-smoking gender- and age-matched volunteers. RESULTS: Osteopenic syndrome (T-test < -1SD) was recorded in 43 (78%) of the 55 examined patients with COPD. In 29 (52%) of them, T-test was lower in two zones towards osteoporosis in 14 (25%) towards osteopenia. In patients with COPD, TNF-alpha concentrations were significantly higher than that in the control group. At the same time, TNF-alpha levels correlated positively with the bone resorption marker BCL (r = 0.52; p = 0.042) and negatively with OPG (r = 0.56; p = 0.003). A direct correlation was established between serum OPG concentrations and BMD in both L(II)-L(IV) and FN (r = 0.56; p < 0.01 and r = 0.47; p < 0.05, respectively) CONCLUSION: The patients with COPD were found to have lower BMD, elevated TNF-alpha concentrations, an increased bone resorption marker, and lower serum OPG levels. The associations between the levels of OPG, TNF-alpha, and BMD suggest that these markers are implicated in the pathogenesis of osteopenic syndrome in COPD.
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