These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury].
    Author: Zhang HY, Yi XN, Liu YH, Lao ML, Zhang XF.
    Journal: Zhong Yao Cai; 2010 May; 33(5):763-7. PubMed ID: 20873562.
    Abstract:
    OBJECTIVE: To study The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury. METHODS: PC12 cells were treated with puerarin for 0.5 h, then incubated with Abeta(25-35) (50 micromol/L) for 24 h to investigate the production of reactive oxygen species (ROS), mitochondrial membrane potential levels and Caspase-3 activation; The expressions of Bax, bcl-2 were measured by Western Blotting. RESULTS: Preincubation of the cell with puerarin could inhibit the ROS and increase mitochondrial membrane potential levels. Puerarin was also found to increase the Bcl-2/Bax ratio and reduce Caspase-3 activation. CONCLUSION: Puerarin may act as an intracellular ROS scavenger, and its antioxidant properties may protect against Abeta(25-35)-induced cell injury.
    [Abstract] [Full Text] [Related] [New Search]