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  • Title: Palladium-catalyzed decarboxylative couplings of 2-(2-azaaryl)acetates with aryl halides and triflates.
    Author: Shang R, Yang ZW, Wang Y, Zhang SL, Liu L.
    Journal: J Am Chem Soc; 2010 Oct 20; 132(41):14391-3. PubMed ID: 20873805.
    Abstract:
    Pd-catalyzed decarboxylative cross-couplings of 2-(2-azaaryl)acetates with aryl halides and triflates have been discovered. This reaction is potentially useful for the synthesis of some functionalized pyridines, quinolines, pyrazines, benzoxazoles, and benzothiazoles. Theoretical analysis shows that the nitrogen atom at the 2-position of the heteroaromatics directly coordinates to Pd(II) in the decarboxylation transition state.
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