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  • Title: Estimation of maximal work rate based on the 6-minute walk test and fat-free mass in chronic obstructive pulmonary disease.
    Author: Cavalheri V, Hernandes NA, Camillo CA, Probst VS, Ramos D, Pitta F.
    Journal: Arch Phys Med Rehabil; 2010 Oct; 91(10):1626-8. PubMed ID: 20875524.
    Abstract:
    OBJECTIVE: To propose a predictive equation of the maximal work rate (Wmax) in patients with chronic obstructive pulmonary disease (COPD) based on the product of 6-minute walking test (6MWT) and fat-free mass (FFM) and to compare it with a previously proposed equation based on the product of 6MWT and body weight (BW). DESIGN: Descriptive (cross-sectional) study. SETTING: University-based rehabilitation center. PARTICIPANTS: Patients with COPD (N=53; 30 men; forced expiratory volume in 1 second, 45%±15% predicted). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Three Wmax were produced: Wmax_real (obtained from the maximal cycle ergometry test), Wmax_BW (estimated from the product of 6MWT and BW), previously proposed by Hill et al. (Arch Phys Med Rehabil 2008; 89(9):1782-7); and Wmax_FFM (estimated from the product of 6MWT and FFM). RESULTS: The equation derived from a regression model to estimate Wmax_FFM was as follows: -27.9717+3.7792*(6MWT*FFM). Wmax_real correlated better with Wmax_FFM (r=.64) than with Wmax_BW (r=.54). There was no difference between Wmax_FFM (median [interquartile range], 41 [29-50] W) and Wmax_real (40 [20-50] W, P=.88), whereas Wmax_BW (60 [52-69] W) significantly overestimated Wmax_real (P<.0001). CONCLUSIONS: In patients with COPD, Wmax is better estimated by an equation including the product of 6MWT and FFM than by a previously proposed equation including the product of 6MWT and body weight.
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