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  • Title: Application of a prediction rule to discriminate between aseptic and bacterial meningitis in adults.
    Author: Doolittle BR, Alias A.
    Journal: Hosp Pract (1995); 2009 Dec; 37(1):93-7. PubMed ID: 20877176.
    Abstract:
    INTRODUCTION: Differentiating between aseptic and bacterial meningitis presents a difficult diagnostic challenge. Accurately ruling out bacterial meningitis may reduce unnecessary hospitalization, patient morbidity, and utilization of resources. This study applies a prediction rule previously developed in the pediatric population to an adult cohort. METHODS: We performed a retrospective chart review of all patients admitted to an urban community hospital in the United States between 1994 and 2007. RESULTS: One hundred eleven patients met the inclusion criteria. Twenty-two (20%) had bacterial meningitis and 89 (80%) had aseptic meningitis. The prediction rule generated a negative predictive value of 100% and a sensitivity of 100%, successfully ruling out all patients with aseptic meningitis. CONCLUSIONS: The prediction rule, previously validated in a pediatric population, was accurate in ruling out bacterial meningitis in an adult cohort. Prospective validation in an adult population is warranted.
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