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  • Title: Chiral Brønsted acid catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones: short access to optically active 2- and 3-substituted indole derivatives.
    Author: Sakamoto T, Itoh J, Mori K, Akiyama T.
    Journal: Org Biomol Chem; 2010 Dec 07; 8(23):5448-54. PubMed ID: 20877865.
    Abstract:
    The asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones catalyzed by chiral phosphoric acid is reported. A wide range of indoles and 4,7-dihydroindoles were allowed to react with α,β-unsaturated ketones to give the corresponding 1,4-adducts in good to high chemical yields and with excellent enantioselectivities.
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