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  • Title: [Interrelationship between the thiamine content, thiamine diphosphate-dependent enzyme activity and reduced glutathione level in the rat liver].
    Author: Parkhomenko IuM, Chernysh IIu, Protasova ZS, Donchenko GV.
    Journal: Ukr Biokhim Zh (1978); 1990; 62(6):52-8. PubMed ID: 2087793.
    Abstract:
    Changes in the amount of thiamine, reduced glutathione, thiamine diphosphate-dependent dehydrogenase activity has been traced after thiamine injection to thiamine-deficient rats and oxythiamine to normal rats. The obtained data show that a drop in reduced glutathione level was a primary reason of the alpha-keto-acid dehydrogenase activity reduction under conditions of the thiamine deficiency. The existence of immediate connection between thiamine and glutathione metabolism is supposed.
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