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  • Title: 3-O-methyl-D-glucose uptake by erythrocytes of normal and diabetic subjects.
    Author: Gomis R, Tomas C, Novials A, Malaisse WJ.
    Journal: Acta Diabetol Lat; 1990; 27(4):279-83. PubMed ID: 2087928.
    Abstract:
    The uptake of 3-O-[14C]methyl-D-glucose was measured in erythrocytes of normal and non-insulin-dependent diabetic subjects. In normal subjects, the uptake of the sugar was rapid, saturable, temperature-sensitive and inhibited by cytochalasin B. Over 30 s incubation at 20 degrees C, the uptake of 3-O-[14C]methyl-D-glucose (20 mM) was lower in diabetic than in normal subjects. These findings raise the view that an alteration of hexose transport into insulin-insensitive cells may participate to the perturbation of glucose homeostasis in diabetic patients.
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