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  • Title: [Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles].
    Author: Lu XD, Zhao GS.
    Journal: Zhongguo Yao Li Xue Bao; 1990 May; 11(3):229-31. PubMed ID: 2087996.
    Abstract:
    The effects of metoclopramide (MCP) on Vmax of action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. MCP 10-550 mumol/L abbreviated the action potential duration at 90% repolarization (APD90) and decreased the maximal rate of rise of action potential (Vmax) dose-dependently. MCP caused rate-dependent and voltage-dependent reductions of Vmax and retardation of the recovery of Vmax. The results present the possible causes of depressant effect of MCP on Na channel.
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