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  • Title: HIV-associated tuberculous meningitis--diagnostic and therapeutic challenges.
    Author: Marais S, Pepper DJ, Marais BJ, Török ME.
    Journal: Tuberculosis (Edinb); 2010 Nov; 90(6):367-74. PubMed ID: 20880749.
    Abstract:
    HIV-associated tuberculous meningitis (TBM) poses significant diagnostic and therapeutic challenges and carries a dismal prognosis. In this review, we present the clinical features and management of HIV-associated TBM, and compare this to disease in HIV-uninfected individuals. Although the clinical presentation, laboratory findings and radiological features of TBM are similar in HIV-infected and HIV-uninfected patients, some important differences exist. HIV-infected patients present more frequently with extra-meningeal tuberculosis and systemic features of HIV infection. In HIV-associated TBM, clinical course and outcome are influenced by profound immunosuppression at presentation, emphasising the need for earlier diagnosis of HIV infection and initiation of antiretroviral treatment.
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