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  • Title: Synthesis of certain thiosemicarbazide and triazole derivatives as potential antimicrobial agents.
    Author: Ashour FA, Almazroa SA.
    Journal: Farmaco; 1990 Nov; 45(11):1207-18. PubMed ID: 2088364.
    Abstract:
    Two novel series of thiosemicarbazide derivatives were synthesized: 2-[4-(substituted thiocarbamoylhydrazinocarbonyl) phenoxymethyl]-1H-benzimidazoles and 1-benzyl-2-[4-(substituted thiocarbamoylhydrazinocarbonyl) phenoxymethyl]-1H-benzimidazoles, and cyclised to 2-[4-(4-substituted-4H-1,2,4-triazole-5-thion-3-yl)phenoxymethy ]-1H-benzimidazoles and 1-benzyl-2-[4-(4-substituted-4H-1,2,4-triazole-5- 5-thion-3-yl)phenoxymethyl]-1H-benzimidazoles, respectively. The antimicrobial activity of the prepared compounds was tested.
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