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  • Title: Interactive proteomics research technologies: recent applications and advances.
    Author: Petschnigg J, Snider J, Stagljar I.
    Journal: Curr Opin Biotechnol; 2011 Feb; 22(1):50-8. PubMed ID: 20884196.
    Abstract:
    Proteins rarely exert their function alone. They normally function in multiprotein complexes that play central roles in all biological functions. Thus, it is not surprising that the investigation of protein-protein interactions on a global scale, of so-called interactomes, has become crucial to modern molecular biology. Dissecting partners in protein complexes gives insight into their molecular function and can help in understanding disease-related mechanisms, ultimately resulting in better drug target definition. A variety of methods exist to unravel protein interaction circuitries and recently, significant progress has been made in adapting these tools for the generation of large-scale interaction datasets. Here, we present an overview of the latest advances and applications of interactive proteomics research technologies.
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