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  • Title: Gd-complexes of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs).
    Author: Kim HK, Park JA, Kim KM, Nasiruzzaman SM, Kang DS, Lee J, Chang Y, Kim TJ.
    Journal: Chem Commun (Camb); 2010 Nov 28; 46(44):8442-4. PubMed ID: 20886175.
    Abstract:
    We report the synthesis of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H(2)O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R(1) relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.
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