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  • Title: Trypanocidal activity of lipophilic diamines and amino alcohols.
    Author: Júnior CO, Alves RO, Rezende CA, da Costa CF, Silva H, Le Hyaric M, Fontes AP, Alves RJ, Romanha AJ, de Almeida MV.
    Journal: Biomed Pharmacother; 2010 Nov; 64(9):624-6. PubMed ID: 20888176.
    Abstract:
    Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth. The most active ones were compounds 3, 4 and 5 with a IC₅₀ of 31.2 μg/mL, activity similar to the reference drug crystal violet.
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