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  • Title: Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response.
    Author: Fendt M, Buchi M, Bürki H, Imobersteg S, Ricoux B, Suply T, Sailer AW.
    Journal: Behav Brain Res; 2011 Feb 02; 217(1):1-9. PubMed ID: 20888368.
    Abstract:
    The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.
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