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  • Title: Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae.
    Author: Park SR, Paik JH, Ahn MS, Park JW, Yoon YJ.
    Journal: J Microbiol Biotechnol; 2010 Sep; 20(9):1295-9. PubMed ID: 20890094.
    Abstract:
    Recently, recombinant Streptomyces venezuelae has been established as a heterologous host for microbial production of flavanones and stilbenes, a class of plant-specific polyketides. In the present work, we expanded the applicability of the S. venezuelae system to the production of more diverse plant polyketides including flavones and flavonols. A plasmid with the synthetic codon-optimized flavone synthase I gene from Petroselium crispum was introduced to S. venezuelae DHS2001 bearing a deletion of the native pikromycin polyketide synthase gene, and the resulting strain generated flavones from exogenously fed flavanones. In addition, a recombinant S. venezuelae mutant expressing a codon-optimized flavanone 3beta-hydroxylase gene from Citrus siensis and a flavonol synthase gene from Citrus unshius also successfully produced flavonols.
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