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  • Title: Evaluation of the cytotoxicity of some Mannich bases of acetophenone against the EMT6 tumour.
    Author: Dimmock JR, Erciyas E, Raghavan SK, Kirkpatrick DL.
    Journal: Pharmazie; 1990 Oct; 45(10):755-7. PubMed ID: 2089386.
    Abstract:
    1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably.
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