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  • Title: [Neuroendocrine changes in patients with inflammatory diseases and colonic cancer].
    Author: Rakhimova OIu, Paĭzullaeva ZK, Aleksandrov VB.
    Journal: Klin Med (Mosk); 2010; 88(4):56-60. PubMed ID: 20919572.
    Abstract:
    The study included 60 patients of whom 20 presented with colonic cancer, 20 with ulcerative colitis UC), and 20 with Crohn's disease (CD). Control group was comprised of 20 healthy subjects. It was shown that UC and CD can be regarded as apudopathies based on reduced melatonin production associated with altered proliferative activity, apoptosis, and accumulation of free radicals. UC and CD patients with high p53, PCNA, and oxidative stress levels both with and without dysplasia of intestinal epithelium are at risk of developing colonic cancer and require efficacious preventive treatment with early diagnosis of oncological problems.
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