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  • Title: [Clinical observation on effect of shenqi guchong recipe in treating peri-menopausal anovulatory dysfunctional uterine bleeding].
    Author: Ye Q, Song W, Zhang LJ.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 2010 Jul; 30(7):686-8. PubMed ID: 20929121.
    Abstract:
    OBJECTIVE: To investigate the effect and hemostatic mechanism of Shenqi Guchong Recipe (SGR) in treating peri-menopausal anovulatory dysfunctional uterine bleeding (ADUB) of qi deficiency blood stasis syndrome type (QDBS). METHODS: Patients of ADUB-QDBS were assigned to two groups, the 47 patients in the treated group administering orally with SGR and the 31 in the control group treated with Kunning Oral Liquid. The hemostatic effect, and the changes before and after treatment of 6-ketoprostaglandin 1alpha (6-K-PGF1 alpha), thromboxane B2(TXB2), T-lymphocyte subsets (CD3 and CD8, CD4/CD8 ratio) in menstrual blood, and serum calcium level in patients were observed. RESULTS: The hemostatic effect in the treated group [85.1% (40/47)] was better than that in the control group [51.6% (16/31)], significant difference was shown between groups (P < 0.05). Changes of 6-K-PGF1 alpha TXB2, and 6-K-PGF1 alph/TXB2 ratio in the treated group were significant after treatment and showed significant difference as compared with those in the control group (P < 0.05 or P < 0.01). Meantime, serum Ca2+ level was increased and parameters of T-lymphocyte subsets improved significantly in the treated group (P < 0.05 or P < 0.01), also statistically different to those in the control group (P < 0.05). CONCLUSION: SGR shows obvious hemostatic effect in treating patients with ADUB of QDBS type, and the mechanism may be related to its actions for improving microcirculation, enhancing immune function, and improving uterine local micro-environment, etc.
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