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  • Title: Premonitory symptoms in migraine without aura: a clinical investigation.
    Author: Santoro G, Bernasconi F, Sessa F, Venco A.
    Journal: Funct Neurol; 1990; 5(4):339-44. PubMed ID: 2093052.
    Abstract:
    Thirty-three out of 100 patients affected by migraine without aura, reported premonitory symptoms in at least 50% of attacks and were considered to be affected by complete or premonitory common migraine. This group had a greater positive familiarity for migraine, a lower mean age of onset, and a higher average number of trigger factors compared with other patients. These three differences were statistically significant; hence we hypothesized that patients with migraine attacks generally preceded by premonitory symptoms have a stronger constitutional migraine trait with a premature weakening of their antinociceptive adaptation systems to the environment and to stressful events.
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