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  • Title: Aversive properties of bombesin in rats.
    Author: Meisenberg G, Simmons WH, Lorens SA.
    Journal: Pharmacol Biochem Behav; 1990 Dec; 37(4):689-92. PubMed ID: 2093172.
    Abstract:
    Aversive properties of bombesin were determined in the conditioned place-preference paradigm in rats and compared with the effects on spontaneous behavior. Bombesin induced excessive grooming and/or scratching behavior at doses of 80 ng, 400 ng, and 2.0 micrograms ICV. In the conditioned place-preference paradigm, doses of 400 ng and 2.0 micrograms ICV induced a profound aversion to the environment in which the animals had received peptide treatment. Eighty ng were partially effective, and 16 ng did not induce a significant change in preference. The grooming/scratching behavior was attenuated by pretreatment with 4 mg/kg morphine-sulfate. These results show that bombesin is strongly aversive at doses that induce grooming/scratching behavior. Although the relationship between these different effects is not known, the similarity in their dose-response relationship suggests that they may be mediated by a common mechanism.
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