These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Intensity-modulated radiotherapy for oropharyngeal squamous cell carcinoma.
    Author: Mendenhall WM, Amdur RJ, Morris CG, Kirwan JM, Li JG.
    Journal: Laryngoscope; 2010 Nov; 120(11):2218-22. PubMed ID: 20938964.
    Abstract:
    OBJECTIVES/HYPOTHESIS: To report the outcomes after intensity-modulated radiotherapy (IMRT) for patients with oropharyngeal squamous cell carcinoma. STUDY DESIGN: Retrospective review. METHODS: Between July 2001 and March 2007, a total of 130 patients were treated with definitive IMRT for squamous cell carcinoma of the oropharynx. Forty-seven patients (36%) had T3 (26 patients) or T4 (21 patients) cancers and 117 patients (90%) had overall stage III to IV disease. The fractionation schedules employed included the following: once daily, 12 patients (9%); hyperfractionation, three patients (2%); and concomitant boost, 115 patients (89%). Seventy-nine patients (61%) received adjuvant chemotherapy, and 54 patients (42%) underwent a planned neck dissection. Median follow-up was 3.5 years, (range, 0.2-7.7 years). Median follow-up for surviving patients was 3.8 years (range, 2.1-7.7 years). RESULTS: The 5-year local control rates were as follows: T1, 93%; T2, 91%; T3, 82%; T4, 67%; and overall, 87%. The 5-year local-regional control rates were as follows: stage I to II, 92%; stage III, 72%; stage IVA, 94%; stage IVB, 71%; and overall, 84%. The 5-year distant metastasis-free survival rate was 93%. The 5-year cause-specific and overall survival rates were 85% and 76%, respectively. Severe late complications occurred in 11 patients (8%). CONCLUSIONS: In our experience, IMRT resulted in local-regional control rates that are comparable to those achieved with more conventional techniques with a similar risk of severe complications.
    [Abstract] [Full Text] [Related] [New Search]