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  • Title: Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells.
    Author: Choi YH, Yoo DS, Cha MR, Choi CW, Kim YS, Choi SU, Lee KR, Ryu SY.
    Journal: J Nat Prod; 2010 Nov 29; 73(11):1863-7. PubMed ID: 20939516.
    Abstract:
    Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.
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