These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Preparation of protein transduction domain-fused peptidyl prolyl cis/trans isomerase Pin1.
    Author: Ohashi T, Teshima S, Hidaka M, Uchida T.
    Journal: Biosci Biotechnol Biochem; 2010; 74(10):2067-70. PubMed ID: 20944414.
    Abstract:
    The phenotypes of mice lacking peptidyl prolyl cis/trans isomerase Pin1 (Pin1(-/-)) indicated that deficient Pin1 might be related to a variety of diseases. We created TAT-Pin1, a fusion protein of human immunodeficiency virus 1 trans-activator of transcription factor with Pin1. Treatment of HeLa cells with TAT-Pin1 increased the ratio of the S phase. Moreover, TAT-Pin1 restored the proliferating function of Pin1(-/-) mouse embryonic fibroblasts which cannot restart proliferation after G0 arrest. These results indicate that TAT-Pin1 is useful in studying the functions of Pin1 and can be developed as a macromolecular drug for diseases related to Pin1 loss.
    [Abstract] [Full Text] [Related] [New Search]