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  • Title: 1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors.
    Author: Deev SL, Yasko MV, Karpenko IL, Korovina AN, Khandazhinskaya AL, Andronova VL, Galegov GA, Shestakova TS, Ulomskii EN, Rusinov VL, Chupakhin ON, Kukhanova MK.
    Journal: Bioorg Chem; 2010 Dec; 38(6):265-70. PubMed ID: 20947122.
    Abstract:
    A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from condensed 1,2,4-triazolo[5,1-c][1,2,4]triazines and 1,2,4-triazolo[1,5-a]pyrimidines, structural analogues of natural nucleic bases. Antiherpetic activity and cytotoxicity of the compounds were studied. The corresponding triphosphates of several active compounds were prepared and tested as inhibitors of DNA synthesis catalyzed by herpes simplex virus polymerase. The potential mechanism of their action is blocking of DNA dependent DNA polymerase, a key enzyme of viral replication.
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