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  • Title: [Syndrome of inappropriate antidiuretic hormone secretion following adjuvant CDDP and 5-FU administration in a patient with esophageal carcinoma].
    Author: Horio T, Tsujimoto H, Akase T, Sakamoto N, Yaguchi Y, Hiraki S, Aiko S, Takechi H, Hase K, Maehara T.
    Journal: Gan To Kagaku Ryoho; 2010 Oct; 37(10):1945-8. PubMed ID: 20948261.
    Abstract:
    A case of hyponatremia following the first course of systemic adjuvant chemotherapy with cisplatin (CDDP) and 5-FU in a previously treated patient with esophageal cancer is reported. A 61-year-old man was admitted to our hospital for adjuvant chemotherapy after transthoracic esophagectomy and 3-field lymphadenectomy for esophageal cancer. Six days following chemotherapy, his serum sodium concentration was found to be 118 mEq/L, without edema or dehydration. This hyponatremic state was diagnosed as the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) induced by CDDP, based on the hypo-osmolality of his serum and urine, and an inappropriate level of plasma vasopressin.
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