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  • Title: No link of serotonin 2C receptor editing to serotonin transporter genotype.
    Author: Lyddon R, Cuppen E, Haroutunian V, Siever LJ, Dracheva S.
    Journal: Neuroreport; 2010 Dec 08; 21(17):1080-4. PubMed ID: 20948451.
    Abstract:
    RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.
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