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  • Title: Structure and cytotoxicity of diterpenoids from Isodon eriocalyx.
    Author: Li XN, Pu JX, Du X, Lou LG, Li LM, Huang SX, Zhao B, Zhang M, He F, Luo X, Xiao WL, Sun HD.
    Journal: J Nat Prod; 2010 Nov 29; 73(11):1803-9. PubMed ID: 20949916.
    Abstract:
    A new ent-atisanoid, eriocatisin A (1), six new ent-abietanoids, eriocasins B-E (2-4, 7), 3-acetyleriocasin C (5), and 3β-acetoxyeriocasin D (6), and seven new ent-kauranoids, maoesins A-F (8, 10-14) and 3α-acetoxy-maoesin A (9), together with 21 known compounds, were isolated from the aerial parts of Isodon eriocalyx. The structures of 1-14 were determined by spectroscopic data interpretation. All compounds isolated were evaluated for their in vitro growth inhibitory activity against the HT-29, BEL-7402, and SK-OV-3 human cancer cell lines. Compounds 17, 18, and 20 showed inhibitory effects for all three tumor cell lines used, with IC(50) values in the range 2.1-7.3 μM.
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