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  • Title: Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma.
    Author: Baró C, Espinet B, Salido M, García M, Sánchez B, Florensa L, Bellosillo B, Serrano S, Solé F.
    Journal: Leuk Res; 2011 Feb; 35(2):256-9. PubMed ID: 20952062.
    Abstract:
    Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its genetic hallmark. We present six cases of a series of 75 well diagnosed FL patients in which variant fluorescence in situ hybridization (FISH) patterns for this rearrangement were found. Moreover, G-banding cytogenetics and polymerase chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL.
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