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  • Title: [Treatment of anemia in patients with renal failure using erythropoietin obtained by genetic recombination].
    Author: Wiecek A, Kokot F, Grzeszczak W, Klin M.
    Journal: Pol Tyg Lek; ; 45(38-39):782-6. PubMed ID: 2095546.
    Abstract:
    In 5 haemodialyzed patients with end-stage renal failure an effect of human recombinant erythropoietin (r-huEpo) on haemoglobin, haematocrit and iron metabolism was studied. After 12 weeks of the treatment, a significant increase in haemoglobin and haematocrit but significant decrease in plasma ferritin were noted. During r-huEpo treatment, one patients presented clinical symptoms of increased blood coagulation whereas another patients an increase in blood pressure. r-huEpo did not influence leukocytes and platelets count as well as liver function tests. Our results suggest, that r-huEpo is highly effective and safe in the treatment of anaemia in patients with chronic uraemia. Iron metabolism, blood pressure and blood coagulation must be monitored during therapy with r-huEpo.
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