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  • Title: Evolving therapies to treat retroglossal and base-of-tongue obstruction in pediatric obstructive sleep apnea.
    Author: Wootten CT, Shott SR.
    Journal: Arch Otolaryngol Head Neck Surg; 2010 Oct; 136(10):983-7. PubMed ID: 20956744.
    Abstract:
    OBJECTIVE: To describe our experience treating retroglossal and base-of-tongue collapse in children and young adults with obstructive sleep apnea using combined genioglossus advancement (Repose THS; MedtronicENT, Jacksonville, Florida) and radiofrequency ablation of the tongue base. DESIGN: Retrospective institutional review board-approved analysis of 31 operations. SETTING: Tertiary pediatric medical center. PATIENTS: Thirty-one patients with a mean age of 11.5 years (age range, 3.1-23.0 years). INTERVENTIONS: Combined genioglossus advancement and radiofrequency ablation. MAIN OUTCOME MEASURES: Preoperative and postoperative polysomnographic data were evaluated for each patient. Success of surgery was determined using the criteria of a postoperative apnea-hypopnea index of 5 or fewer events per hour, without evidence of hypoxemia (oxygen saturation as measured by pulse oximetry), and without prolonged hypercarbia (end-tidal carbon dioxide). RESULTS: Thirty-one patients who underwent genioglossus advancement were analyzed. Nineteen (61%) had Down syndrome. The overall success rate was 61% (19 of 31) (58% [12 of 19] success among patients with Down syndrome and 66% [7 of 12] success among patients without Down syndrome). Overall, the mean apnea-hypopnea index improved from 14.1 to 6.4 events per hour (P < .001); the mean nadir oxygen saturation as measured by pulse oximetry during apnea improved from 87.4% to 90.9% (P = .07). CONCLUSIONS: Pediatric obstructive sleep apnea refractory to adenotonsillectomy that is due to retroglossal and base-of-tongue collapse remains difficult to treat. However, most patients in this analysis benefited from combined genioglossus advancement and radiofrequency ablation.
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