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  • Title: [Lymphocytic myocarditis. Response to treatment with immunosuppressive drugs].
    Author: Arteaga-Fernánez E, Barretto AC, Mady C, Higuchi ML, Fiorelli AI, Bellotti G, Jatene AD, Pileggi F.
    Journal: Arq Bras Cardiol; 1990 Sep; 55(3):161-5. PubMed ID: 2095721.
    Abstract:
    PURPOSE: To evaluate immunosuppressive drugs on the treatment of myocarditis. PATIENTS AND METHODS: Right ventricular endomyocardial biopsy was performed in 102 patients with dilated cardiomyopathy. According to histopathologic aspect the patients were divided into two groups: I--with active lymphocytic myocarditis (ALM); II--without ALM: 51 patients. Ten patients from group I (Ib), with moderate or intense myocarditis were treated with prednisone and azathioprine during six months. RESULTS: After six months of observation, in group Ia (41 patients): 41 improved, 22% worsened and 12% died; in group Ib (10 patients): 60% improved, 10% worsened and 30% died; 51 patients in group II: 59% improved, 17% worsened and 10% died. Control biopsy on group Ib showed decrease of myocarditis in 62%. CONCLUSION: Immunosuppressive drugs do not always improve quality of life, or increase the survival, although in more than 50% of the cases it was possible to control inflammatory process.
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